A Nature-Inspired Novel Technique to Overcome Present Limitations of Enzyme Immobilization

Denmark leads the global enzymes market with 70% of world production. Despite exponentially growing enzyme demand in some industries, efficient enzyme recycling remains a challenge due to the inadequate existing immobilization techniques. Indeed, while immobilization improves and recyclability, enzyme leakage and activity loss associated with immobilization persist. These issues perpetuate the use of less eco-friendly processes, particularly chemical processes. 
Ineffective enzyme immobilization hinders substrate access to the active site, which is the main responsible for the low activity after immobilization. To address this, we propose two strategies: the use of new immobilization supports, such as MOFS, and use of nature-inspired immobilization strategies, like protein glycosylation. Our innovative approach aims to ensure optimal activity of enzymes, e.g. laccases. Success could significantly cut enzyme process costs.