SpectISO: Spectroelectrochemical Integration for Advancing Ion-Selective Optodes

Ionic species can be measured using either ion-selective electrodes or optical sensors known as optodes. However, both approaches face significant limitations, particularly in connection to optodes’ pH cross-sensitivity. Such limitations have essentially prevented their direct application in media where pH varies in space or time, typically for many environmental, medical, and industrial settings. My simulations suggest that modern dynamic electrochemical methods can be applied to relieve pH cross-sensitivity in optical sensors. This project aims to demonstrate how controlling electric potential in optodes can enhance the accuracy of analysis. If successful, this project will not only advance state-of-the-art technologies but also mark a new era in analytical tools, making ion measurement in complex samples more reliable.