New letters to the DNA alphabet

DNA functions as an information carrier in all living organisms on our planet. Even though the genetic code has only four letters, or bases (A,T, C and G), it can translate to immense biodiversity around us. But is it only 4 letters? Maybe we are overlooking some of the important information by using our standard methodologies of examining DNA? This project is aimed to explore the role of queuosine (Q), or related to it compounds, as alternative letters in DNA of newly discovered viruses of bacteria. The key questions addressed include which letter is being replaced with Q, what is the exact mechanism of its synthesis inside the host cell and how is it accomplished by this group of viruses? This experiment can lead to important discoveries concerning use of hyper modified bases and how does it affect the very core processes in biology.