Deciphering the mechanisms of gene regulation on tissue development

The development of tissues relies on the selective activation of genes in different cell types. Enhancers are short DNA-sequences spread across the genome that regulate the extent of gene activation in all cells of an organism. However, it has so far been impossible to measure their activity in single cells. To overcome this we will establish new methods and identify key gene regulatory mechanisms defining how cell types and tissues emerge. The grant will fund one PhD student and one postdoc.