De novo design of photoactive proteins

Photoactive proteins are important light-responsive tools for basic science and biotechnology. Existing examples of these tools such as fluorescent proteins, light-controlled protein switches, and photoenzymes have been derived from natural proteins. We will use recent advances in computational protein design to create new artificial photoactive proteins with functions beyond those found in nature. The grant will fund the recruitment of one Ph.D. student and one postdoc as well as new equipment.