Cellular function at respiratory extremes

Oxygen supply and waste product removal are crucial for cellular function. However, the fish retina operates under proton and oxygen levels ten times higher than in other tissues, which would kill most other animal cells. This project seeks to identify the cellular defense mechanisms that allow the fish retinal cells to function in these extreme conditions, which will push our understanding of the limits of cellular life. The grant will allow the recruitment of two Ph.D. students and one postdoc.