Unravelling the Structure and dynamics of chromatin repair

DNA damage leads to aging, neurodegenerative diseases, and cancer. Despite progress in identifying repair factors, we do not fully understand how they act in the three-dimensional context of DNA (chromatin), and why their disruption leads to disease. Using structural biology, our group aims to unveil the structure and dynamics of DNA repair complexes on chromatin. Our goal is to provide mechanistic insights essential for developing effective prevention and therapeutic strategies in the future. The grant will allow the recruitment of one Ph.D. student and one postdoc.